bacterium100sEngineering tools for Gram positive bacteria

Gram positive bacteria like Bacillus subtilis provide a number of benefits for synthetic biologists. B. subtilis is non-tranformable and naturally transformable, with an efficient system for homologous transformation. Gram positive bacteria provide the bulk of industrially important species and their architectures allow high level secretion of enzymes and other proteins. The Synthetic Biology group at the University of Cambridge is developing tools for work with B. subtilis. The pages in this section provide access to recent papers and relevant websites in the field.

 
Publication Date: 2013 Apr 17 PMID: 23599001 Authors: Ma, Q. - Yin, Y. - Schell, M. A. - Zhang, H. - Li, G. - Xu, Y. Journal: Nucleic Acids Res The circular chromosome of Escherichia coli has been suggested to fold into a collection of sequentially consecutive domains, genes in each of which tend to be co-expressed. It has also been suggested that such domains, forming a partition of the genome,...
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Publication Date: 2013 Apr 23 PMID: 23617824 Authors: Obara, B. - Roberts, M. - Armitage, J. - Grau, V. Journal: BMC Bioinformatics BACKGROUND: Microscopy image segmentation lays the foundation for shape analysis, motion tracking, and classification of biological objects. Despite its importance, automated segmentation remains challenging for several widely used non-fluorescence,...
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In 2010 there were more than 200 million cases of malaria, and at least 655,000 deaths. The World Health Organization has recommended artemisinin-based combination therapies (ACTs) for the treatment of uncomplicated malaria caused by the parasite Plasmodium falciparum. Artemisinin is a sesquiterpene endoperoxide with potent antimalarial properties, produced by the plant Artemisia annua....
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P. furiosus Bacterium Missouri University of Science and Technology To find a way of fending off global warming, scientists sometimes look to nature. Plants, after all, use photosynthesis to snap up carbon dioxide, the biggest source of our climate change woes. So we get inventions like artificial leaves and ambitious projects like a plan to give fish photosynthesizing powers. One of the...
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Publication Date: 2013 Apr 9 PMID: 23572583 Authors: Espinar, L. - Dies, M. - Cagatay, T. - Suel, G. M. - Garcia-Ojalvo, J. Journal: Proc Natl Acad Sci U S A Gene regulatory circuits can receive multiple simultaneous inputs, which can enter the system through different locations. It is thus necessary to establish how these genetic circuits integrate multiple inputs as a function of their...
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Publication Date: 2013 Mar PMID: 23526885 Authors: Perego, M. Journal: PLoS Biol Signal transduction systems are influenced by positive and negative forces resulting in an output reflecting the sum of the opposing forces. The Rap family of regulatory protein modules control the output of two-component signal transduction systems through proteinratioprotein and proteinratiopeptide interactions....
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Nature Biotechnology 31, 350 (2013). doi:10.1038/nbt.2537 Authors: Linfeng Huang, Jingmin Jin, Padraig Deighan, Evgeny Kiner, Larry McReynolds & Judy Lieberman Synthetic small interfering RNAs (siRNAs) are an indispensable tool to investigate gene function in eukaryotic cells and may be used for therapeutic purposes to knock down genes implicated in disease. Thus far, most synthetic siRNAs...
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Back in my college days, I took microbiology and spent plenty of time in the lab culturing various bacteria. My microbiology professor hated it if we drew patterns or other than random circles or zigzags in our petri dishes. I once made the mistake of growing a nice E. coli ‘S’ and had to start over. Zachary Copfer, a microbiologist with a penchant for art has developed a new process of...
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The Algae Curtain-a is living photosynthesising textile installation that was developed as part of the Energy Futures Project by studio Loop.pH in Lille, France. Commissioned by EDF and Lille3000 for the Festival Fantastic 2012, it forms part of the ongoing research by Loop.pH studio into living metabolic textiles. The design is made up of transparent tubes knotted into large architectural...
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Scientists at the University of Alberta and University College Cork in Ireland have found a way to use bacteria to prevent mold from eating up your leftover food. Their research is based on a study of sourdough bread, which doesn’t go moldy like other types of bread. Special bacteria that produce fungus-resistant acids during sourdough production may play a key role in extending the shelf...
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