Cambridge website for Synthetic Biology Resources
 
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Compiled by Jim Haseloff at the University of Cambridge
This site contains details of recent papers and activity in Synthetic Biology, with particular emphasis on: (i) development of standards in biology and DNA parts, (ii) microbial and (iii) plant systems, (iv) research and teaching in the field at the University of Cambridge, (v) hardware for scientific computing and instrumentation, (vi) tools for scientific productivity and collected miscellany. 

 

www.synbio.org.uk

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SynBio calendar

  • 18 Feb

    Technology is driving revolutionary changes in biology. Over the past decade, scientists and engineers have begun to define the path forward in the genomic era. Systems Biology has arisen...

  • 17 Mar

    Now that we know the sequences of many genomes, from a wide variety of organisms and even from individuals with unique characteristics, many researchers have turned to making intentional...

  • 09 Apr

    The developments within synthetic biology promise to change the world in significant ways. Yet synthetic biology is largely unrecognized within conservation. The purpose of the meeting...

  • 09 Jun

    (Re-)constructing and Re-programming Life This conference will provide an in-depth discussion forum among practitioners of the various fields underlying Synthetic Biology. It aims to...

  • 09 Jul

    The BioBricks Foundation is pleased to announce The BioBricks Foundation Synthetic Biology 6.0 Conference (SB6.0), which will take place on July 9-11, 2013 at Imperial College, London,...

  • 30 Jul

    This course will focus on how the complexity of biological systems, combined with traditional engineering approaches, results in the emergence of new design principles for synthetic...

18 Feb - 23 Mar
09 Apr - 15 Jun
09 Jul - 13 Aug

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Synbio news:
2 Oct 2010

The Purple Cauliflower Arises from Activation of a MYB Transcription Factor.: "Publication Date: 2010 Sep 20 PMID: 20855520
Authors: Chiu, L. W. - Zhou, X. - Burke, S. - Wu, X. - Prior, R. - Li, L.
Journal: Plant Physiol

Anthocyanins are responsible for the color of many flowers, fruits, and vegetables. An interesting and unique Purple (Pr) gene mutation in cauliflower confers an abnormal pattern of anthocyanin accumulation, giving the striking mutant phenotype of intense purple color in curds and a few other tissues. To unravel the nature of the Pr mutation in cauliflower, we isolated the Pr gene via a combination of candidate gene analysis and fine-mapping. Pr encoded a R2R3 MYB transcription factor that exhibited tissue-specific expression, consistent with an abnormal anthocyanin accumulation pattern in the mutant. Transgenic Arabidopsis and cauliflower plants expressing the Pr-D allele recapitulated the mutant phenotype, confirming the isolation of the Pr gene. Up-regulation of Pr specifically activated a bHLH transcription factor and a subset of anthocyanin structural genes (BoF3'H, BoDFR, and BoLDOX ) to confer ectopic accumulation of pigments in the purple cauliflower. Our results indicate that the genetic variation including a Harbinger DNA transposon insertion in the upstream regulatory region of the Pr-D allele is responsible for the up-regulation of the Pr gene in inducing phenotypic change in the plant. The successful isolation of Pr provides important information on the regulatory control of anthocyanin biosynthesis in Brassica vegetables, and offers a genetic resource for development of new varieties with enhanced health-promoting properties and visual appeal.

(Via Plant Physiology.)

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